Simvastatin Hydroxy Acid Sodium Salt
Simvastatin Hydroxy Acid Sodium Salt
CAS: 101314-97-0
Molecular Formula: C25H41NaO6
Simvastatin Hydroxy Acid Sodium Salt - Names and Identifiers
Simvastatin Hydroxy Acid Sodium Salt - Physico-chemical Properties
| Molecular Formula | C25H41NaO6 |
| Molar Mass | 460.59 |
| Melting Point | >122°C (dec.) |
| Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| Appearance | White powder solid. |
| Color | White to Pale Beige |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| In vitro study | Simvastatin sodium shows a inhibition of HMG-CoA reductase in human lymphoblasts and SV40 transformed MRCS fibroblasts.Simvastatin sodium (100 μM) inhibits the Na + /H + antiport activity leading to a fall of intracellular pH and to a reduced cell proliferation.And the inhibitory effect is prevented by mevalonate but not dolichol or squalene. |
| In vivo study | Simvastatin sodium (oral administration; 8 mg/kg; 18 days) reduces plasma cholesterol levels 33%, simvastatin can be used in combination with ezetimibe to treat dyslipidemia. |
Simvastatin Hydroxy Acid Sodium Salt - Introduction
Simvastatin hydroxy acid sodium (Tenivastatin sodium; Simvastatin Impurity A sodium) is an active hydrolytic metabolite of simvastatin (HY-17502). Simvastatin is a competitive HMG-CoA reductase inhibitor with a Ki value of 0.2 nM.
Last Update：2022-10-16 17:31:12
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